c-Myc
The MYC proto-oncogene encodes the transcription factor, c-Myc protein, which binds DNA to regulate transcription. c-MYC is the cellular homolog of the retroviral v-myc oncogene, which when altered by chromosomal translocation, or amplification, or when exhibiting deregulated expression, plays a significant role in mutagenesis of tumors including bladder and breast cancers. c-Myc binds with a variety of protein interactors.
The c-Myc transcription factor is a helix-loop-helix leucine zipper protein that dimerizes with an obligate partner, Max, to bind DNA sites, 5'-CACGTG-3', termed E-boxes. c-Myc also binds DNA sites that vary from this palindromic hexanucleotide canonical sequence [3]. [s]
Oncogenes: c-Fos : c-Jun : c-Myc : c-Sis : Ras : Rb : v-Fos : v-Sis : v-Myc :
Tumor Suppressor Genes: TP53
Tables Oncogenes Proto-oncogenes Malignant Transformation Regulatory Proteins Sequences Cell signaling Cell Adhesion Apoptosis vs Necrosis Apoptosis
. c-Myc Cancer Gene . Genome Biology .
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The c-Myc transcription factor is a helix-loop-helix leucine zipper protein that dimerizes with an obligate partner, Max, to bind DNA sites, 5'-CACGTG-3', termed E-boxes. c-Myc also binds DNA sites that vary from this palindromic hexanucleotide canonical sequence [3]. [s]
Oncogenes: c-Fos : c-Jun : c-Myc : c-Sis : Ras : Rb : v-Fos : v-Sis : v-Myc :
Tumor Suppressor Genes: TP53
Tables Oncogenes Proto-oncogenes Malignant Transformation Regulatory Proteins Sequences Cell signaling Cell Adhesion Apoptosis vs Necrosis Apoptosis
. c-Myc Cancer Gene . Genome Biology .
Top ▲
Labels: c-Myc, leucine zipper protein, muagenesis, proto-oncogene, transcription factor