Carcinogenesis and Neoplasia ... a Companion Site.


Cancers arise when cells escape normal controls on cellular proliferation. Cancer is not a single disease, rather the term encompasses a group of conditions that share the characteristic process of uncontrolled cellular proliferation of cells that are typicallly capable of local infiltration into other tissues (invasion). This propensity for invasion and migration is associated with the capacity to metastasize to sites distant from the point of origin. Benign tumors evidence as local overgrowth, but fortunately have minimal or no propensity for tissue infiltration and metastasis. Cancers originating in the same tissue/organ can vary considerably in degree of undifferentiation, sensitivity to chemotherapeutic agents, growth rate, invasiveness, and metastatic potential.

Alteration of a gene that normally controls cell growth can promote the uncontrolled growth characteristic of cancer. The normal forms of dominant genes that function in the various signal transduction cascades that regulate cell growth, proliferation and differentiation are termed proto-oncogenes, and the malignantly transformed genes are termed oncogenes.

For example, mutation in a proto-oncogene, such as a gene which encodes an intracellular signaling protein that is normally activated only by extracellular growth factors, converts the proto-oncogene into an oncogene. The malignantly transformed oncogene encodes an altered form of the signaling protein that now behaves as though activated even in the absence of growth factor binding. The malignant cell line has escaped normal gene regulation and cell cycle control mechanisms and exhibits unchecked proliferation.

A propensity for invasion and metastasis is a critical feature that distinguishes malignancies from benign tumors.

There are many excellent sites with information for those affected by cancer, so the purpose of this site, in conjunction with the companion sites, is an exploration of the cell and molecular biology of malignancy.

synonyms : cancer, tumor, malignancy, neoplasm; cancerous, tumorous, malignant, neoplastic; cancer, neoplasia, oncology.

¤¤ adenoviruses ¤ amplification ¤ carcinogenesis ¤ c-Fos ¤ c-Jun ¤ c-Myc ¤ c-Sis ¤ estrogen receptors ¤ gene amplification ¤ genetic predispositon ¤ HBV ¤ HIV ¤ HPV ¤ HTLV-I ¤ immune evasion ¤ irradiation ¤ malignant transformation ¤ metastasis ¤ mitogens ¤ mutagens ¤ MYC ¤ mutations ¤ neoplasia ¤ neoplastic mutations ¤ NF-κB ¤ non-mutagenic carcinogens ¤ oncogenes ¤ p53 ¤ proliferation ¤ proto-oncogenes ¤ radiation ¤ Ras ¤ Rb ¤ retroviral mechanisms of carcinogenesis ¤ retroviruses ¤ signaling molecules ¤ SRC genes ¤ T-antigens ¤ TP53 ¤ tumor antigens ¤ tumor suppressors ¤ tumorigenic viruses ¤ viral carcinogens ¤ v-Fos ¤ v-Sis ¤ v-Myc ¤



Labels: , , , , , , , ,


Anonymous Anonymous said...

Hello. This post is likeable, and your blog is very interesting, congratulations :-). I will add in my blogroll =). If possible gives a last there on my blog, it is about the DVD e CD, I hope you enjoy. The address is A hug.

12:54 PM  
Anonymous Anonymous said...

免費視訊聊天室 -
免費視訊聊天室 -
台灣自拍偷拍 -
模特兒寫真 -
美女寫真 -
寫真女郎AV -
台灣美女自拍寫真圖片 -
內衣模特兒寫真 -
波霸美女寫真 -
寫真女郎AV貼片 -
美女裸體寫真 -
日本模特兒寫真 -
性感寫真 -
蓬萊仙山清涼寫真秀 -
情色寫真 -
日本漫畫卡通 -
卡通金瓶梅漫畫 -
18限卡通漫畫 -
卡通色情圖片 -
台灣AV女優 -
AV女優寫真 -
後宮電影院 -
後宮電影 -
後宮電影入口 -
後宮電影院入口 -
免費下載洪爺後宮 -
後宮電影首頁入口 -
後宮情色網 -
後宮電影首頁 -
嘟嘟成人網 -
嘟嘟成人 -
嘟嘟貼圖區 -
嘟嘟成人貼片 -
情色貼圖-嘟嘟成人網 -
嘟嘟成人貼圖 -
嘟嘟成人網站 -
洪爺影城 -
洪爺免費電影下載 -
洪爺色情小說 -
洪爺色情網站 -
洪爺影城-影片中心 -
小說頻道 -

11:07 PM  
Blogger xenatrathumtibet said...

Good guide to cancer...I'm thinking about doing some research on the topic once I go off to college. Have you heard of the CDX-110 vaccine? It's for brain tumors.

3:07 PM  

Post a Comment

<< Home

. . . proliferating since 10/06/06